Boston Professional Events List

Genome rearrangements and mutation signatures in development and cancer

Apr 18, 2017 - 04:00 PM - Apr 20, 08:15 PM
1, Kendall Sq

ZIP: 02139
Phone: (877) 774-8286

This conference will welcome over 18 speakers to Boston for three days of lectures, networking opportunities, and poster sessions. 

Merck Boston Auditorium, Boston, US
18-20 April, 2017

Program summary

This meeting will bring together leading researchers in genomics and classical mechanistic biology, in an effort to decode the information contained in mutation signatures, genome rearrangements, and alterations of karyotype in human disease. The program will highlight the latest developments in this exciting field. This meeting is co-sponsored by the Department of Cell Biology at Harvard Medical School, and we hope that it will also foster new collaborations between groups working in this research area. This meeting will select short talks from submitted abstracts.

Download the conference program


Registration includes:

  • Attendance to scientific sessions and conference materials
  • Refreshments and lunches during the conference
  • Drinks and networking reception April 18th

**"Local Student" pricing is only applicable to students, postdocs, faculty, and researchers from the following institutions: Harvard University, Harvard Medical School, Harvard School of Dental Medicine, Harvard T. H. Chan School of Public Health, Harvard affiliated hospitals and institutions, and MIT.  All "Local Student" registrants will be reviewed for approval by the Department of Cell Biology at Harvard Medical School. Registrants not approved will be contacted to pay full price ("Delegate" or "Student") in order to attend. In order to be approved by the Department of Cell Biology at Harvard Medical School, registrants must use their work email addresses.

Keynote speakers

  • Titia de Lange, The Rockefeller Institute, US
    “Telomere crisis as a source of genome rearrangements”
  • Professor Sir Mike Stratton, Wellcome Trust Sanger Institute, UK
    (Keynote sponsored by Harvard Medical School, Department of Cell Biology)
    "Signatures of mutational processes in cancer"

Confirmed speakers

  • ​​​​​​Fred Alt, Boston Children's Hospital 
    “Recurrently breaking genes in brain precursor cells: are there any functional or disease-relevant overlaps with those of B cells?”
  • Angelika Amon, MIT, US
    “How aneuploidy affects tumorigenesis”
  • Rameen Beroukhim, Dana-Farber
    “Mechanistic and selective forces shaping rearrangement profiles in cancer” Cancer Institute , US
  • Peter Campbell, Wellcome Trust Sanger Institute, UK
    “Patterns of structural variation in 2,600 cancer genomes”
  • Don Cleveland, University of California- San Diego, US
    “Genome rearrangements and mutation signatures in development and cancer”
  • Luca Comai, University of California - Davis, US
    “Plant genome instability mediated by centromere failure”
  • Steve Elledge, Harvard Medical School , US
    “How aneuploidy drives cancer”
  • Gad Getz, Broad Institute, US
  • Dmitry Gordenin, NIEHS, US
    “Knowledge-based analyses of mutation signatures reveal sources and mechanistic details of mutagenesis in humans”
  • James Haber, Brandeis University, US
    “Mutations and chromosomal alterations arising from repair of double-strand breaks in budding yeast”
  • Emily Hatch, Fred Hutchinson Cancer Research Center, US
    “Causes/consequences of nuclear envelope rupture in micronuclei”
  • Maria Jasin, Memorial Sloan Kettering Cancer Center, US
    “Protecting the genome by homologous recombination”
  • Jim Lupski, Baylor College of Medicine, US
    “Complex genomic rearrangements (CGR) and multiple de novo CNV (MdnCNV) — what can they teach us about mutational mechanisms?”
  • Anna Malkova, University of Iowa Carver College of Medicine, US
    “Genetic instability resulting from DNA synthesis associated with double-strand break repair”
  • Serena Nik-Zainal, Wellcome Trust Sanger Institute, UK
    “Advances in the understanding of mutational signatures in human cells”
  • David Pellman, Dana-Farber Cancer Institute, US
    “Complex chromosomal rearrangements from nuclear envelope disruption”
  • Ralph Scully, Harvard Medical School, US
    “Mechanisms of genomic instability at stalled replication forks”


Meeting organizers

Topic overview:

  • Genome evolution in tumorigenesis
  • Mutational signatures in development and cancer
  • Analysis of structural variations in the cancer genome: detection, classification and underlying mechanisms
  • Basic mechanisms underlying genomic instability
  • Evolution of karyotype and mitotic control


Start Time End Time
April 18, 2017 15:00 April 20, 2017 17:00

Call for abstracts

This meeting will select short talks from submitted abstracts. Please submit yours by February 1, 2017.
Poster abstracts will be accepted through to March 1, 2017.

Download our abstract guidelines 

Venue directions

Merck Boston Auditorium,
33 Avenue Louis Pasteur,
Boston, MA 02115
Map of Merck Boston Location

Terms and conditions

Delegates are advised to ensure they have adequate travel insurance to cover their attendance at the conference in case of incident, or cancellation due to circumstances beyond Abcam'scontrol.

  • All fees paid to Abcam, including registration fees are non-refundable
  • Substitute delegates can be made at any time by contacting Abcam Events.


Important note regarding Hotel Accommodations:

Abcam does not have an affiliated hotel agency for this event.

Please be careful of direct approaches from companies offering hotel reservations for this event. Reservations made by unaffiliated organizations may appear to be for lower rates, however they may be illegitimate, have unreasonable cancellation or change penalties, or be completely non-refundable. Please be aware of, and report any unauthorized solicitation to Abcam.


Event Categories
Keywords: fun, analysis, analyses, biology , class , conference , development , drinks, Fun , Health


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